IGF1 and Osteopenia: These results indicated that BMP-6 exerted an osteoinductive effect at least in part through the IGF-1 and EGF pathways29, which was observed both in a murine model of osteopenia and in the human osteoblastic cell line as well as through the application of BMP-6/ACS onto critical-size supra-alveolar defects that enhanced periodontal wound healing/regeneration.