In the multivariate logistic regression model, low birth weight (aOR 10.76, 95% CI 0.82–141.78) and elevated CRP after NEC diagnosis (aOR 39.21, 95% CI 6.62–249.2) seem to have increased risks for NEC deterioration, while NEC infants with CHD had a decreased risk of deterioration (aOR 0.11, 95% CI 0.01–0.92) (Table 4). This evidence concerns the gene CRP and necrotizing enterocolitis.