Moreover, placental upregulation of endogenous sFlt1 that acts as an inhibitor of VEGF and placental growth factor (PlGF) signaling, has been linked to the pathogenesis of preeclampsia (PE)5,6 and possibly hemolysis, elevated liver enzyme levels, and low platelet levels (HELLP) syndrome that exhibits liver dysfunction7,8. This evidence concerns the gene VEGFA and preeclampsia.