Our data led us to propose a complex model in which the IRE1/XBP1 signaling axis would promote GBM aggressiveness through the enhancement of tumor immune infiltration and angiogenesis as well as tumor cell invasiveness properties, whereas RIDD (of mRNA and miRNA) would play an anti‐tumoral role by selectively reducing tumor angiogenesis as well as tumor cell invasiveness (Fig 6A). The gene discussed is ERN1; the disease is glioblastoma.