ERN1 and cancer: Moreover, large‐scale sequencing studies on human cancer tissue samples performed by The Cancer Genome Atlas (TCGA) initiative (Cancer Genome Atlas Research Network, 2008; Parsons et al, 2008) revealed the presence of three somatic mutations on the IRE1 gene in GBM leading to the S769F, Q780* (Greenman et al, 2007), and P336L (Parsons et al, 2008) variants.