The ~2 times longer incubation period in GH-iCJD than DM-iCJD cases resembles the longer incubation period associated with the peripheral (e.g., in the peritoneal cavity) vs. central (e.g., intracerebral) inoculations of prions or Aβ seeds in Tg mouse models for these proteinopathies [20, 36]. Here, GH1 is linked to proteostasis deficiencies.