Furthermore, Aβ and p-tau pathologies (but not fully developed AD) have been replicated following Aβ or p-tau intracerebral or peripheral inoculations to transgenic mice that express human APP harboring AD pathogenic mutations as well as wild type human APP, indicating that Aβ pathology is transmissible [11, 20, 47, 48, 70]. This evidence concerns the gene MAPT and Alzheimer disease.