Little is known about the speriolin-like protein SPATC1L, but elevated methylation at the small noncoding RNA VTRNA2-1 has previously been reported to predict poor prognosis in acute myeloid leukemia [51] and other types of cancer [13], consistent with the positive association we found between VTRNA2-1 methylation and lung cancer and mature B-cell neoplasm (Fig. 7d, e). This evidence concerns the gene SPATC1L and B-cell neoplasm.