High expression of AFAP1-AS1 is associated with malignancy, metastasis and poor prognosis in various cancers, such as hepatocellular carcinoma, nasopharyngeal carcinoma, esophageal carcinoma, colorectal cancer, cholangiocarcinoma, and gallbladder cancer [27–35]. The gene discussed is AFAP1; the disease is carcinoma of esophagus.