The changes in SQSTM1/p62 levels and LC3 were exacerbated in GBA+/L444P mice treated with MPTP compared to that in WT mice treated with MPTP (Additional file 9: Figure S9), suggesting that inhibition of autophagy due to GBA mutation could be a mechanistic basis for the increased susceptibility of PD. Here, GBA1 is linked to Parkinson disease.