In 2004, Kimonis and colleagues provided the first evidence that mutations in the VCP gene result in inclusion body myopathy with Paget disease of bone and frontotemporal dementia (IBMPFD), which is a multiple tissue disorder associated with myopathy, bony defects and dementia [13]. The gene discussed is VCP; the disease is inclusion body myopathy with Paget disease of bone and frontotemporal dementia.