A univariate analysis revealed that hematological subtypes (p = 0.038), diabetes mellitus (p = 0.04), liver cirrhosis (p < 0.001), low anti-HBs titer values (p = 0.002), and positive anti-HBc (p = 0.005) were risk factors of HBsAg positive seroconversion. Here, KRT88P is linked to diabetes mellitus.