A multivariate analysis revealed that diabetes mellitus (p = 0.005, OR: 0.218, 95% CI: 0.076–0.629), allogeneic transplantation (p = 0.013, OR: 0.182, 95% CI: 0.047–0.701), liver cirrhosis (p < 0.001, OR: 0.002, 95% CI: 0.000–0.047), low anti-HBs titer values (p = 0.016, OR: 0.020, 95% CI: 0.001–0.480), and positive anti-HBc (p = 0.013, OR: 0.070, 95% CI: 0.009–0.571) were independent risk factors of HBsAg positive seroconversion. Here, KRT88P is linked to cirrhosis of liver.