IL-6 expression was tested in 1/72 (1.4%) patient and resulted positive.[3] IL-6 overexpression and high serum level of IL-6 were associated with inflammatory constitutional symptoms such as fever, weight loss, fatigue, and a variety of laboratory abnormalities, such as acute-phase reaction, thrombocytosis, anemia, and elevated sedimentation ratio. The gene discussed is IL6; the disease is anemia (phenotype).