Using a combination of click chemistry to detect vDNA and immuno-labelling to detect PML-NB intrinsic host factors, PML (the main scaffolding protein of PML-NBs; [48]) and Daxx (a core constituent protein of PML-NBs; [48]) were observed to stably colocalize with vDNA over the time course of infection (30–90 mpi; Fig 2A). Here, PML is linked to infection.