So, this effect may berelated to soluble or cell surface CD40L and the enhancedFAS expression should predispose cells to apoptosis (28).In line with our findings Pellat-Deceunynck et al. (29) andFunakoshi et al. (30) showed the role of CD40 ligation ontumor cells of multiple myeloma and primary high-gradeB-cell lymphoma, respectively. The gene discussed is CD40LG; the disease is plasma cell myeloma.