We show that the association of the 9p21 locus withCAD in T2DM patients is likely to be due to ANRILby dysregulating neighboring or inflammatory genes.However, to confirm this claim, further mechanisticstudies are required to know whether ANRIL is a cause ofCAD in T2DM patients or an associated biomarker. This evidence concerns the gene CDKN2B-AS1 and type 2 diabetes mellitus.