Rieussetreported that dimethyl a-(dimethoxyphosphinyl)pchlorobenzylphosphate (SR-202) as a selective syntheticinhibitor of PPAR-γ inhibits adipocyte differentiation andimproves insulin sensitivity in diabetic ob/ob mice (38).Thus, PPARγ antagonists may be useful for the treatmentof obesity-related insulin resistance. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.