For example, one potential concern was that the inclusion of germline samples from the TCGA cohort might result in an overrepresentation of alleles in genes associated with hereditary endocrine tumors; although this cohort does not include endocrine tumors relevant to the genes under study (e.g., PPGL, medullary thyroid cancer), it was reassuring that the TCGA samples did not contribute an excess of rare SNVs or likely pathogenic alleles in the genes investigated, with the possible exception of VHL, in which the inclusion of renal carcinoma cases may have introduced a risk of bias. This evidence concerns the gene VHL and renal carcinoma.