To date, upstream regulators of SALL4 expression in leukemia remain poorly understood, although OCT4, GATA4, GATA6, STAT3, TBX5, the WNT/β-catenin signaling factors, and micorRNAs such as miR-98, miR-33b and miR-294 are reported in other cell systems [8–10, 76, 90, 91]. Here, SALL4 is linked to leukemia.