KMT2A and leukemia: ChIP assays with sequencing (ChIP-Seq) assays with mouse MLL-AF9 transformed leukemic cells are also performed [50], which identified that SALL4 binds to 451 genes including MLL-AF9 targets (Meis1, Hoxa9), MLL-r leukemia-related genes (Cebpα, Id2, Elf1, Evl, Flt3, Nf1, Tal1, Tcf7l1, Nkx2–3), HOX factors (Hoxa-9, −10, −11, −13), Notch ligand Jag2, and Wnt/β-catenin regulator Wnt7b. Further, loss of SALL4 downregulated the expression levels of Bmi1, cMyb, Runx1, Meis1, and HOX factors.