Of note, DNA methylation modifications of the SALL4 promoter may play a role, −studies using B-ALL cell lines and patient samples detected hypomethylation of the SALL4 CpG islands spanning the exon1-intron1 region [57], which has also been observed in MDS and AML patients, and this hypomethylation correlates with high SALL4 expression [92, 93]. Here, SALL4 is linked to acute myeloid leukemia.