CD4 and viral infectious disease: Earlier studies demonstrate that human cells may increase the m6A levels to get rid of viral infection.18b In particular, HIV-1 mRNA contains multiple m6A modifications and the infection in CD4+ T-cells modifies both host and viral RNAs with m6A. Importantly, HIV-1 infections can generate ROS from phagocytes in vivo,35 thus yielding substantial levels of 8-oxo-dGTP in the deoxynucleotide precursor pool.