MSH2 and Inherited cancer-predisposing syndrome: Forty-two percent (n = 34) of patients carried a DV in one of the classic HBOC- or LS-associated genes (BRCA1/2, MLH1, MSH2, MSH6, and PMS2), while the remaining 58% (n = 47) carried a DV in high risk genes for breast and other hereditary cancer syndromes (n = 17) or in genes associated with moderate to low risk (n = 30).