Out of the 56 DV-positive individuals with a family history of HBOC-associated cancers, only 32% (n = 18) were found to have DV in BRCA1/2 and of the 47 DV-positive individuals with a family history of LS-associated cancer, only 21% (n = 10) carry DV in LS genes. Here, BRCA1 is linked to cancer.