Previously we have proposed that, in the range of normal concentrations (0.35–1.0 μmol/L), ADMA confers protection against atherosclerosis [6], a lesion where iNOS is induced, by causing a more pronounced inhibition on iNOS due to the lower EC50 value of ADMA for iNOS than that for eNOS [39, 40]. This evidence concerns the gene NOS2 and atherosclerosis.