Herein, to investigate the clinicopathological features of PMLP and the significance of CRMP4 methylation in PMLP, the methylation of CRMP4 promotor in each group [10 PMLP patients, 20 cases of prostate adenocarcinoma tissue, 10 cases LPCa-LN (−) and 10 cases mPCa-LN (+)] was analyzed statistically. This evidence concerns the gene PLLP and prostate adenocarcinoma.