CRMP4 methylation in 10 cases PMLP, 20 cases of prostate adenocarcinoma (10 patients with localized PCa and 10 patients with metastatic PCa), 10 cases of negative lymph nodes of localized prostate adenocarcinoma (LPCa-LN (−)) and 10 cases of positive lymph nodes of metastatic prostate adenocarcinoma (mPCa-LN (+)) paraffin embedded tissues were determined. This evidence concerns the gene PLLP and posterior cortical atrophy.