The current findings are based on physician‐diagnosed HF, which has yielded estimates of HF incidence consistent with those of earlier reports.32, 33 Moreover, the determinants of HF in this study population (including obesity, NT‐proBNP, lung function, and heavy drinking)16, 17, 18, 34 generally accord with prior data and suggest that the HF outcome used was valid. The gene discussed is NPPB; the disease is obesity due to melanocortin 4 receptor deficiency.