The latest approaches in synthetic lethality aim to use various PARP1 inhibitors (talazoparib, veliparib, rucaparib, niraparib) for the treatment of cancers with defects other than BRCA1 deficiencies, including defects in PALB2, FANCD2, RAD51, ATM, MRE11, p53, XRCC1 and LSD1[22]. This evidence concerns the gene PARP1 and cancer.