The cell proliferation curve showed that there was no significant difference in the proliferation of DLD-1 colon cancer cells before 24 h; the proliferation of colon cancer cells in CXCL12 siRNA group was significantly lower than those in the untransfected and control siRNA groups after 48, 72, 96, 120 h (P < 0.01, compared with the untransfected and control siRNA groups). Here, CXCL12 is linked to colonic neoplasm.