In addition, the relationships of phosphorylation of components of MAPK/PI3K/Ap-1 signaling pathway with CXCL12 were examined in this study, and the correlative mechanism for the inhibitive effect of CXCL12 siRNA on the proliferation and invasion of colon cancer cells was investigated. The gene discussed is CXCL12; the disease is malignant colon neoplasm.