In addition, CD99 engagement increases NK cell-mediated tumor lysis by inducing HSP70 expression (Husak and Dworzak 2012) and inhibits tumor cell migration and metastasis through different mechanisms, including the suppression of C-SRC and ROCK2 activities (Pinca et al. 2017; Scotlandi et al. 2007; Zucchini et al. 2014) or the blockade of CD98-mediated β1 integrin signaling, which can suppress tumor progression by inhibiting the positive feedback loop involving CD98/β1 integrin/focal adhesion kinase (FAK)/RHOA/ROCK (Lee et al. 2017). Here, RHOA is linked to neoplasm.