In addition, Ras-related Sec4p, the product of the budding yeast SEC4 gene, whose discovery in 1987 established the Rab field [36], shares an identical switch II region with human Rab8A/B, meaning that phospho-specific antibodies designed to recognise these human proteins might also be useful to evaluate whether Sec4p phosphorylation occurs at this site in model organisms from yeast to flies, another useful LRKK2 model of PD [37]. The gene discussed is AGFG1; the disease is Parkinson disease.