HH group had the highest levels of the protein in comparison with hypercapnia group (NLRP3: df = 1, F = 222.94, P < 0.01; pro-caspase-1: df = 1, F = 227.86, P < 0.01; caspase-1: df = 1, F = 117.93, P < 0.01; IL-1β: df = 1, F = 103.25, P < 0.01) and Hypoxemia group (NLRP3: df = 1, F = 23.81, P < 0.01; pro-caspase-1: df = 1, F = 40.04, P < 0.01; caspase-1: df = 1, F = 10.77, P < 0.01; IL-1β: df = 1, F = 25.62, P < 0.01) (Figs. 3a, b and 4a, c). This evidence concerns the gene NLRP3 and Hypoxemia.