CTNNB1 and dengue disease: Patients there DF is associated with the autosomal dominant familial adenomatous polyposis (FAP) syndrome characterized by a germline mutation of the adenomatous polyposis coli (APC) gene and a risk of 30% developing DF and patients with sporadic DF (harboring the CTNNB1 mutation (beta-catenin) in the tumor, which are considered mutually exclusive.