BCAR1 and cancer: We assume a complex situation as a result of 1) minor differences resulting in high statistical significance because of the very high sample numbers, 2) ERG driven sudden up-regulation of BCAR1 expression and 3) regression to the mean in tumor progression to nodal metastasis which means increase of BCAR1 staining in the ERG negative and decrease of BCAR1 staining in the ERG positive cancer subset.