Jonusiene et al. demonstrated that expression of core elements of the Notch signaling pathway (NOTCH1, NOTCH2, NOTCH3 and NOTCH4) was down-regulated in UCEC compared to adjacent nontumor endometrial tissue, implying the tumor suppressor roles of Notch signaling pathway in UCEC [37]. This evidence concerns the gene NOTCH4 and neoplasm.