CA4 and HMOX1 achieved the best AUC performance (AUC = 0.9 and AUC = 0.89) in liver hepatocellular carcinoma, LTC4S and NEUROD1 in lung adenocarcinoma (AUC = 0.998 and AUC = 0.994), FANCA and ARG2 in lung squamous cell carcinoma (AUC = 0.992 and AUC = 0.956). The gene discussed is CA4; the disease is squamous cell lung carcinoma.