The genes TAP1 and FEN1 achieved the best AUC performance in bladder urothelial carcinoma (AUC = 0.928 and AUC = 0.903), CA4 and RRM2 were the best predictors in breast invasive carcinoma cancer (AUC = 0.89 and AUC = 0.88), ACADM and CD22 in colon adenocarcinoma (AUC = 1), ALDH6A1, GLA and MCM3 in esophageal carcinoma (AUC = 1), GAD1 and PLIN1 in head and neck squamous cell carcinoma (AUC = 0.83, and AUC = 0.83). The gene discussed is ACADM; the disease is head and neck squamous cell carcinoma.