In the T2DM cohort, mean (± SD) serum C4 levels in the volixibat group were approximately twofold greater on day 14 (59.66 ± 28.221 ng/mL) and day 28 (61.81 ± 22.163 ng/mL) than at baseline (30.15 ± 14.351 ng/mL) (Table 3). This evidence concerns the gene C4A and type 2 diabetes mellitus.