Since it is the epithelial infection that induces the worst symptoms of shigellosis [50], this uncontrolled epithelial expansion indicates that our model’s hypothetical patient (and the average EcSf2a-2 or 2457T study volunteer when protected solely by an anti-LPS or -OMP humoral response) is symptomatic to heavily symptomatic. The gene discussed is OMP; the disease is shigellosis.