FWGE has been reported to increase blastic transformation of peripheral blood T cells by concanavalin A [11], to reduce graft survival in a coisogenic skin transplantation model [11] and to reduce production of IL-4 and IL-10 in a systemic lupus erythematosus model [27], supporting its immunomodulatory properties. This evidence concerns the gene IL10 and systemic lupus erythematosus.