For the LDB3 protein, RBM20 regulates differential inclusion of exon 4 (included in healthy humans or wild type (WT) rats) or exon 5 and 6 (included in the patient with RBM20 mutation or Rbm20 deficient rats), and the isoform switch of LDB3 has been related to DCM [18]. This evidence concerns the gene RBM20 and familial dilated cardiomyopathy.