In the previous researches, a 27.8 kDa protein from flounder gill cells was identified as a receptor mediating LCDV entry and infection; mass spectrometry and western blotting analysis showed that the 27.8 kDa receptor protein had an association with β actin [32,33], and the expression of 27.8 kDa receptor protein was up-regulated post LCDV infection, indicating a positive correlation with efficient LCDV replication in the tissues of flounder and turbot [45,55]. Here, ACTB is linked to infection.