Using 1205Lu melanoma cells stably transduced with a JARID1B-promoter-green fluorescent protein (GFP)-reporter construct [44], we found that a short 2-day exposure to PLX4720 led to a 4-fold enrichment of JARID1B-driven GFP expressing 1205Lu melanoma cells grown as spheroids (data not shown). Here, KDM5B is linked to melanoma.