ALDH2 and oropharynx cancer: According to one meta-analysis and one well-performed study (total of 1189 cases and 3239 controls), ALDH2 deficiency is associated with a 1.68-fold to 2.61-fold oropharyngeal cancer risk in moderate drinkers and 3.57-fold to 7.28-fold risk in heavy drinkers [37,39].