Following the hypothesis that TRPMLs and TPCs play a role in mTOR signaling by affecting MITF/TFEB activity and thus the CLEAR gene network (coordinated lysosomal expression and regulation gene network; [47,48]), a more detailed analysis of TFEB activation (i.e., translocation into the nucleus) and the transcription of TFEB target genes in WT versus TRPML/TPC KD/KO cancer cells is warranted. The gene discussed is TFEB; the disease is cancer.