Altered TFEB expression and/or activity has recently been associated with pancreatic cancer cell proliferation [51] and non-small cell lung cancer motility [52], and Calcagnì et al. recently showed that kidney-specific TFEB overexpression in transgenic mice resulted in renal clear cells, multi-layered basement membranes, severe cystic pathology, and ultimately papillary carcinomas with hepatic metastases [53]. Here, TFEB is linked to familial pancreatic carcinoma.