Mg2+ deficiency has been implicated in many disease processes, including type 2 diabetes (T2DM) [16], Alzheimer’s disease [17], and cancer [18,19,20,21], while Mg2+ supplementation has been shown to be beneficial for blood pressure control, endothelial function, insulin sensitivity and T2DM [22,23,24]. Here, INS is linked to type 2 diabetes mellitus.