Human TERT (hTERT) has been shown in cancer cells to catalyse the creation of double-stranded RNA (dsRNA) from a non-coding RNA template, which is processed as a small interfering RNA (siRNA) and induces silencing, targeting in particular transcription from centromeres and transposons and possibly helping in the maintenance of heterochromatin [73]. The gene discussed is TERT; the disease is cancer.