MYC pathway is known to be activated in the S2 subtype.4 Direct targeting of this pathway has been technically challenging, but BET bromodomain inhibition by a small molecule, (+)-JQ1 has been show to elicit anti-MYC pathway activity.17, 18 To evaluate whether the subtype-dependent response to MYC pathway inhibition can be monitored in hepatoma cells, SNU-387 and SNU-182 (S1-like cells) as well as Huh-7 and Hep G2 (S2-like cells) were treated with (+)-JQ1. Here, MYC is linked to hepatocellular carcinoma.