MVs released from human kidney cancer stem cells contain angiogenic miRNAs and mRNAs that upregulate expression of VEGF receptor-1 (VEGFR1), VEGF and matrix metallopeptidase 2 (MMP2) in lung endothelial cells and stimulate formation of blood vessels, which contribute to lung metastasis (Grange et al., 2011). The gene discussed is MMP2; the disease is kidney cancer.