One possible mechanism for this transformation is that pancreatic cancer cells are able to secrete miR-155-containing exosomes, which can be received by NFs and convert them into CAFs via inhibition of tumor protein p53-inducible nuclear protein 1 (TP53INP1), a target protein of miR-155 (Pang et al., 2015). This evidence concerns the gene TP53INP1 and pancreatic neoplasm.