The evidence of transdifferentiation of c-kit-BMCs was tested by Drs. Wagers and Weissman, which failed to reproduce our early results.6 10 days after myocardial infarction and cell delivery, clusters of GFP-positive cells negative for myocyte and vascular antigens but positive for the myeloid marker Gr-1 were detected, suggesting that BMCs adopt the mature hematopoietic fate in the injured heart. The gene discussed is KIT; the disease is myocardial infarction.