ALB and cholangiocarcinoma: Albumin expression in the perinatal and juvenile liver mirrors the organ’s transition from a haematopoietic to hepatic function and, therefore, constitutive albumin Cre systems result in ductular labelling in the adult.33 This effect has been borne out in a model where kRas mutation and Pten deletion are used to induce CC under control of the Albumin promoter.