Genetic deletion of Mst1 and Mst2 results in massive liver overgrowth and eventually HCC development.56 Disruption of the pathway through liver-specific knock out of WW45, a homolog of Drosophila Salvador, similarly results in liver enlargement accompanied by an HPC response, mediated through phosphorylation and hyperactivation of the downstream effector, Yap. Here, SAV1 is linked to hepatocellular carcinoma.