AKT1 and infarction: IGF-1Ea also induces the expression of the calcineurin splicing variant CnAβ.40 Interestingly, the effects of AAV9.IGF-1Ea are reminiscent of those of CnAβ1 overexpression, which results in Akt activation, improved vascularisation of the infarct region and reduced infarct expansion leading to reduced remodelling and improved cardiac function post-infarction.41,42