Brain injury causes cognitive impairment, increases the accumulation of amyloid precursor protein (APP), extracellular beta amyloid (Aβ) peptide and intracellular neurofibrillary tangles (NFTs) consisting of tau protein associated with inflammatory cytokine release (Johnson et al., 2012; Gupta and Sen, 2016; Kokiko-Cochran et al., 2016; Young et al., 2016). The gene discussed is APP; the disease is Cognitive impairment.