Taken together with the CoREST1 and SIN3A knockdown experiments, these results suggest that the more powerful anti-proliferative action of corin vs. MS-275 in the melanoma and colon cancer cells analyzed may involve its more comprehensive targeting and sustained inhibition of the LSD1-containing CoREST complex relative to other complexes. This evidence concerns the gene RCOR1 and malignant colon neoplasm.