Examination of the tumor tissue recovered from mice treated with corin vs. vehicle showed that tumor cells from the corin-treated animals displayed elevated H3K9 acetylation, H3K4 dimethylation (Fig. 6b), and increased expression of p21, CHOP, and MXD1 (Fig. 6c), consistent with the cell culture experiments. This evidence concerns the gene MXD1 and neoplasm.