The Promyelocytic leukemia (PML) gene was identified as a result of its involvement in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL)15–17, and has since been extensively studied in cancer mainly as a tumor suppressor gene, which controls fundamental biological processes such as apoptosis, cellular proliferation, and senescence18,19. The gene discussed is PML; the disease is acute promyelocytic leukemia.