Although anti-Cxcr2 or anti-Il6R alone was sufficient to impair the maintenance of BA+KLS cells, a concomitant blockade of both Cxcr2 and Il6R resulted in a further reduction of BA+KLS cells in the co-cultures; however, treatment with a single neutralizing antibody was not effective for AML models (Supplementary Fig. 5b). Here, CXCR2 is linked to acute myeloid leukemia.