Importantly, when we narrowed our investigation to focus on responsive models, and analyzed the maintenance of the population of LSCs, identified as BA+GFP+ckit+Lin−Sca1+ cells for the CML model (BA+ KLS cells), and GFP+ckit+ cells for the AML models (AML ckit+ cells), we observed that the reduction in the number of leukemic cells in the co-cultures with MSCs Pml−/− correlated with a progressive decline in the number of LSCs cells (Fig. 3b and Supplementary Fig. 3d, e). This evidence concerns the gene RPS6KB2 and acute myeloid leukemia.