Genetic analysis of a rare type of non-Hodgkin lymphoma, the extranodal NK/T-cell lymphoma nasal type (ENKL), highlights the general importance of chromatin modification and remodeling factors including BCL6 co-repressor, the methyltransferase EZH2 and SUZ12, components of polycomb repressor complex 2 (PRC2), for NK cell pathophysiology (52). The gene discussed is SUZ12; the disease is extranodal nasal NK/T cell lymphoma.