The different trends in lymphocytosis from pretreatment to day 30 between CD49d− and CD49d+ CLL were also observed in a small group of patients (n = 10) of the Mayo cohort, entering the clinical trial NCT02048813 which introduced rituximab after 30 d of ibrutinib (Materials and methods; Table S1). Here, ITGA4 is linked to B-cell chronic lymphocytic leukemia.