ITGA4 and B-cell chronic lymphocytic leukemia: Heterogeneous baseline levels of ALC were found in the different cohorts irrespective of CD49d expression (Fig. 4 A) and, as expected (Herman et al., 2014b; Farooqui et al., 2015; Thompson et al., 2015a), variability in ALC values was observed in both CD49d− and CD49d+ CLL cases upon ibrutinib treatment (Fig. 4 B, top).