CD49d, the α chain of the CD49d/CD29 integrin heterodimer very late antigen 4 (VLA-4), expressed in ∼40% of chronic lymphocytic leukemia (CLL) cases, has emerged as one of the most relevant biological predictors of overall survival (OS) and progression-free survival (PFS) in CLL (Gattei et al., 2008; Shanafelt et al., 2008; Bulian et al., 2014). This evidence concerns the gene ITGA4 and B-cell chronic lymphocytic leukemia.