ITGA4 and B-cell chronic lymphocytic leukemia: We observed a trend toward lower median LN reduction in CD49d+ CLL compared with CD49d− CLL at 2 mo (CD49d+ CLL, n = 20; CD49d− CLL, n = 13; Fig. S2 C, top), which manifested in a significant effect at both 6 mo (CD49d+ CLL, n = 20; CD49d− CLL, n = 13; Fig. S2 C, bottom) and 12 mo (CD49d+ CLL, n = 30; CD49d− CLL, n = 23; Fig. 6, A and B).